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The cholinergic neurons during the PPN and LDT regulate each SNc and VTA neurons by way of activating acetylcholine receptors in these neurons [eight]. Combining optogenetic and Mind slice patch-clamp techniques, Xiao et al. [eight] demonstrated that 5–10?s of optogenetic stimulation of cholinergic projections from the PPN and LDT evokes inward c
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